4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide

Name	NU6140
Synonyms	NU6140 4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide Benzamide, 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-
CAS	444723-13-1

Molecular Formula	C23H30N6O2
Molar Mass	422.52
Density	1.234±0.06 g/cm3(Predicted)
Boling Point	707.8±70.0 °C(Predicted)
Appearance	White to off-white solid.
pKa	9.41±0.10(Predicted)
Storage Condition	Desiccate at +4°C
In vitro study	NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H, with IC 50 s of 6.6, 5.5, 15 and 3.9 μM, respectively. NU6140 increases catalytic activity of capase-9 and capase-3, causes increase in the sub-G1 apoptotic cell population.

biological activity	NU6140 is a selective CDK2-cyclin A inhibitor (IC50,0.41 μM), and its selectivity is 10-36 times that of other CDK. NU6140 effectively inhibited the activity of Aurora A and Aurora B with IC50 values of 67 and 35 nM, respectively. Enhance the effect of inducing apoptosis and anti-tumor effect.
target	cdk2-cyclin A 0.41 μ m (IC 50 ) CDK1-Cyclin B 6.6 μ m (IC 50 ) CDK4-Cyclin D 5.5 μ m (IC 50 ) cdk5-p25 15 μ m (IC 50 ) cdk7-cyclin H 3.9 μ m (IC 50 ) Aurora A 67 nm (IC 50 ) Aurora B 35 nm (IC 50 )
in vitro study	NU6140 is less active on CDK1-cyclin B, CDK4-cyclin d, CDK5-p25 and CDK7-cyclin h, with IC 50 s of 6.6, 5.5, 15 and 3.9 μ m, respectively. NU6140 increases catalytic activity of capase-9 and capase-3, uses increase in the sub-G1 apoptotic cell population.

Last Update：2024-04-09 19:05:06

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Product Name: NU6140 Visit Supplier Webpage Request for quotation
CAS: 444723-13-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide Request for Quotation